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1. To be hopeless; to have no hope; to give up all hope or expectation; -- often with of. 2. To give up as beyond hope or expectation; to despair of. 3. To cause to despair. 4. Loss of hope; utter hopelessness; complete despondency. 5. That which is despaired of. 6. the feeling that everything is wrong and nothing will turn out well
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