1. To make turbid, or muddy, as water. 2. To cloud or stupefy; to render stupid with liquor; to intoxicate partially. 3. To waste or misuse, as one does who is stupid or intoxicated. 4. To mix confusedly; to confuse; to make a mess of; as, to muddle matters; also, to perplex; to mystify. 5. To dabble in mud. 6. To think and act in a confused, aimless way. 7. A state of being turbid or confused; hence, intellectual cloudiness or dullness. 8. informal terms for a difficult situation; "he got into a terrible fix"; "he made a muddle of his marriage"